IM-21 Reviews (Mike Tyson) Legit Supplements That Really Work?

IM-21 is a muscle-building and fat-burning supplement endorsed by Mike Tyson.

By taking IM-21 Burn and IM-21 Build daily, you can enjoy all-day focus, superior strength, and explosive energy, then get deeper sleep, better recovery, and enhanced growth overnight.

Does IM-21 live up to the hype? Should you take Mike Tyson’s IM-21 supplement? Keep reading to discover everything you need to know about IM-21 and how it works.


What is IM-21?

IM-21 is a nutritional supplement sold online through IM-21.com.

By taking IM-21 daily, you can trigger growth mode and get you back into your prime by giving your body the powerhouse nutrients it needs to burn fat and build muscle.

IM-21 is not a pre-workout supplement, nor is it a protein powder. Instead, it’s a combination of two supplements designed to target performance in different ways:

IM-21 Burn: IM-21 Burn is a powdered formula designed to boost all-day focus, promote superior strength, and give you explosive energy. It contains caffeine and other ingredients to boost performance all day long. You mix the powder with water, then drink it daily.

IM-21 Build: IM-21 Build is a sleep and restoration powder. You mix the powder with water, then drink it daily to promote a deeper and more restorative sleep, a faster recovery, and enhanced growth, among other benefits.

As you get older, it’s harder to force your body into growth mode. It’s easy to get stuck in stress mode. IM-21 aims to solve that problem.

To solve that problem, IM-21 contains a blend of energy and anabolism boosting ingredients (like caffeine, creatine, and calcium HMB) with sleep aid ingredients (like valerian, melatonin, and L-tryptophan). You energy your body during the day and then enjoy a deep sleep while giving your body powerful muscle-building ingredients.


IM-21 Benefits

By taking IM-21 Burn and IM-21 Build daily, you can purportedly help support the following benefits:

  • More strength
  • Faster metabolism
  • Better sleep
  • Less body fat
  • Quicker muscle gains
  • Improved focus
  • More motivation

The formula can also help if you struggle with muscle loss, slow metabolism, sleep issues, excess body fat, slow muscle gains, brain fog, low motivation, and fatigue, among other benefits. These issues can inhibit your training results – or decrease all-day energy. IM-21 is designed to help.

How to Use IM-21

Both IM-21 supplements come in the form of a powder. You mix the powder with water, then drink it daily to support muscle growth and performance.

Here are the steps recommended on IM-21.com:

Step 1) Mix IM-21 with Water: Both Burn (AM) and Build (PM) mix easily into 8-10oz of water. Alternatively, you can mix it with a shake, milk, or the beverage of your choice.

Step 2) Enjoy a Delicious Anabolic Drink: Feed your muscles essential amino acids and nutrients packed into each blend, forcing your body into muscle growth mode.

Step 3) Activate Growth Mode: The anabolic activators flip your body’s switch into a fat-burning and muscle-building state and keep you there all day and all night.


IM-21 Ingredients

IM-21 contains different ingredients in the Burn and Build mix. Together, however, Mike Tyson calls IM-21’s ingredients the “iron matrix formula,” delivering trusted ingredients from trusted sources.

Creatine: IM-21 contains creatine, one of the most-studied sports performance supplements ever. Research consistently shows creatine can help build muscle mass, and there’s a reason creatine is the world’s second best-selling supplement after whey protein. Here are some of the key ingredients in IM-21 and how they work:

Anabolism allows your body to build muscle mass, and anabolism is crucial for increasing muscle development. HMB: IM-21 contains HMB, which is clinically proven to be effective for keeping and growing strength and muscle mass, according to IM-21. In fact, the official website described HMB as “possibly the most anabolic substance on earth, gram for gram.”

Vitamin D3: IM-21 contains vitamin D3, which is useful for your bones and muscles – especially when combined with creatine and HMB. Some studies show a 20% increase in strength when taking vitamin D.

Fructose: Fructose is a fruit sugar your body converts into glycogen. Your body’s muscles need glycogen. By taking fructose with creatine, you can also boost absorption and retention.

Glycine: IM-21 contains glycine, the first amino acid ever discovered. Glycine is everywhere in your body, and it plays a vital role in muscle performance and energy.

Protease (Papain): IM-21 contains protease in the form of papain. Papain is a type of protease. It’s a digestive enzyme that helps break down proteins, making it easier for your body to handle, process, and use proteins in the supplements you take. If you’ve ever felt bloated or uncomfortable after taking a protein powder, the protease in IM-21 could help.

L-Glutamine: IM-21 contains glutamine, another amino acid abundant in the body. Your body harvests L-glutamine from muscle tissues when your body is under stress.

Taurine: IM-21 contains taurine, which helps your body produce energy by balancing digestion. Many energy drinks contain taurine for that reason.

Caffeine: Caffeine is a proven fat burner and energy booster, and it’s one of the world’s most popular supplement ingredients. IM-21 contains caffeine to boost energy and provide all-day energy and focus.

L-Phenylalanine: IM-21 contains phenylalanine, an amino acid your body needs but cannot make (like other essential amino acids). You need to get phenylalanine from the foods you eat, and IM-21 provides the phenylalanine you need.

B Vitamins: IM-21 contains three B vitamins, including vitamins B2, B6, and B12. Your body needs B vitamins for energy metabolism, digestion, and other crucial body processes. Vitamin B12 is essential for those on a vegetarian or vegan diet, as there are no excellent plant-based sources of vitamin B12. By taking B vitamin supplements daily, you can boost energy and focus.

Vitamin C: IM-21 contains vitamin C, one of nature’s best antioxidants. It’s also a proven immune booster. Like other antioxidants and immune boosters, vitamin C can support immunity, make it easier to recover from exercise, and support skin health, among other perks.

Cordyceps: Used in traditional Chinese medicine for centuries, cordyceps is a type of mushroom used as an adaptogen, which means it helps your body respond to stress. According to the IM-21 team, the cordyceps in IM-21 will help regulate blood sugar, improve cellular energy (by targeting ATP production), improve strength and energy, and boost stamina, among other benefits.

GABA: GABA is an important amino acid in your brain. Your brain is packed with GABA receptors. Taking GABA as a supplement allows this GABA to cross the blood-brain barrier, triggering the onset of rest, relaxation, and sleep. IM-21 uses GABA to calm the mind as part of the Build formula. Your body builds muscle overnight, and ingredients like GABA help your body get the maximum benefit from your rest.

Valerian: Another popular herbal extract for relaxation, valerian is found in many sleep aid supplements sold online today. Valerian is rich with valerenic acid, which inhibits the breakdown of GABA in the brain. That can mean better rest and better recovery all night long.

Melatonin: IM-21 contains melatonin, one of nature’s best sleep aids. Your body produces melatonin based on its sleep-wake cycles – your circadian rhythm. If your circadian rhythm gets disrupted, it can be difficult for your body to produce melatonin and fall asleep. That’s why some people take melatonin supplements. IM-21 uses a 3mg dose of melatonin to help trigger deep sleep faster without any downsides.

L-Tryptophan: IM-21 contains L-tryptophan, an amino acid linked to sleep and relaxation. Tryptophan is the ingredient in turkey meat that makes you feel sleepy after Thanksgiving dinner. Today, many sleep aid supplements contain tryptophan for better rest and relaxation.

IM-21 Features

IM-21 emphasizes all of the following features, making it superior to other protein powders, creatine, and even HRT, among other supplements and options.

Here are some of the features that make IM-21 superior to competing products, according to IM-21.com:

  • No prescription is needed (as opposed to HRT)
  • No side effects
  • Activates anabolic pathways (unlike protein powder and creatine alone)
  • Scientifically formulated to help burn fat
  • Proven in helping build muscle
  • It makes your food anabolic
  • Simple, safe, and easy
  • It helps with improved sleep and anabolic recovery
  • Provides true cellular fuel
  • Provides clean, all-day energy
  • Backed by a lifetime moneyback guarantee

Scientific Evidence for IM-21

IM-21 Burn and IM-21 Build have not completed clinical trials to verify they work. However, both supplements contain science-backed ingredients that can help you achieve targeted benefits.

IM-21 cites multiple studies validating the various ingredients within the formula. We’ll review some of those studies below to analyze the science behind IM-21.

HMB is one of the key ingredients that makes IM-21 different from protein powders and creatine supplements. IM-21 cites one study where participants took beta-hydroxy-beta-methyl butyrate (HMB) and gained 252% more lean body mass in 12 weeks. Subjects gained 7.4lbs of lean body mass in a 12-week trial compared to 2.1lbs with the control group. Researchers observed no long-term effects due to HMB supplementation, and participants significantly increased hypertrophy, strength, and power by combining HMB with resistance training.

In another study, participants increased their one-rep max by 18% over 35 days, leading to a 200% improvement compared to a placebo. In that study, participants received 3g of creatine per day or 5g of creatine per day, then tested their maximum muscle strength (1RM), upper body endurance (MPU), and abdominal muscle endurance (MSU) after 7, 14, 21, 28, and 35 days. Participants experienced significantly better measurements across all performance measurements (except for abdominal muscle endurance, which did not increase).

IM-21 may help increase testosterone. Good sleep – and good energy – are crucial for testosterone. In one study cited by IM-21, participants gained 25% more total testosterone one year later compared to baseline. Researchers told a group of 165 participants (54 men) to take vitamin D or a placebo for one year in that study. Researchers observed no change in testosterone in the placebo group, yet the vitamin D group significantly increased testosterone.

IM-21 also cites a study proving the ingredients in the formula can help with deep sleep. In the cited study, participants taking valerian increased the deep sleep stage of sleep by 18% compared to a placebo. A group of 16 patients took valerian or a placebo, then experienced significantly better sleep. They took less time falling asleep and spent more time in a restful sleep stage than a placebo.

IM-21 could boost endurance. As proof, the makers of IM-21 cite a study where Cordyceps Sinensis, a mushroom extract within IM-21, boosted endurance by 79% when taken by itself and 139% in conjunction with endurance training. The study aimed to analyze the effectiveness of traditional Chinese medicine. Researchers gave 200mg/kg doses of cordyceps to rats for 15 days, then observed significantly better endurance in the cordyceps group compared to the placebo group.

Overall, IM-21 contains a collection of ingredients to support anabolism, muscle building, recovery, and energy, among other benefits. IM-21 should work as advertised to target effects in two ways, helping you boost overall performance – even if it can’t make you quite as powerful as Mike Tyson.

IM-21 Ingredients Label

Mike Tyson and the IM-21 team disclose all ingredients in IM-21 upfront, making it easy to compare Burn and Build to other energy and sleep supplements sold online today.

Here are all of the ingredients in each IM-21 supplement.



Each packet (7.1g) of Burn contains the following ingredients:

  • 100mg of calcium (7% DV)
  • 1.3mg of vitamin B2 (100% DV)
  • 65mg of vitamin B6 (3,500% DV)
  • 40mcg of vitamin B12 (1,666% DV)
  • 45mg of vitamin C (50% DV)
  • 5,000 IU / 50mg of vitamin D3 (625% DV)
  • 75mg of caffeine
  • 1,500mg of creatine
  • 2mg of fulvic acid
  • 100mg of glycine
  • 500mg of HMB (calcium HMB)
  • 100mg of L-glutamine
  • 40mg of phenylalanine
  • 200K USP of protease/papain (2,000USP/mg)
  • 100mg of taurine
  • Other (inactive) ingredients, including fructose, citric acid, orange flavor, and sucralose
  • Each packet contains 12 calories, 0g of fat, 0g of sodium, and 3g of carbs.


Each packet (6.2g) of Build contains the following ingredients:

  • 100mg of calcium (7% DV)
  • 5,000 IU/ 50mg of vitamin D3 (625% DV)
  • 10mg of cordyceps
  • 1,500mg of creatine
  • 2mg of fulvic acid
  • 100mg of GABA
  • 100mg of glycine
  • 500mg of HMB (calcium HMB)
  • 40mg of L-tryptophan
  • 3mg of melatonin
  • 200K USP of protease/papin (2,000USP/mg)
  • 50mg of valerian root extract
  • Other (inactive) ingredients, including fructose, chocolate fudge flavor, and sucralose
  • Each packet contains 12 calories, 0g of fat, 0g of sodium, 0g of potassium, and 3g of carbs.

IM-21 Pricing

IM-21 is priced at $69 for a one-month supply. You can save money by ordering multiple packages. Each package contains a one-month supply of IM-21, including one month of Burn and one month of Build.

Here’s how pricing breaks down:

  • 1 Month Supply: $69 + $6.95 Shipping
  • 3 Month Supply: $177 + Free US Shipping
  • 6 Month Supply: $234 + Free US Shipping


IM-21 Refund Policy

A lifetime moneyback guarantee backs IM-21.

If you are ever unsatisfied with your order, you can call the company at 866-GET-IM21 (866-438-4621) for a full refund, including shipping, with no questions asked.

Just send back any unused product to the manufacturer to qualify for a refund. If there is no unused product in the packaging, you will still receive a full refund.

About IM-21

IM-21 is a health and nutrition company founded by former undisputed heavyweight champion of the world, Mike Tyson.

The company’s flagship product, IM-21, includes two separate supplements: Burn and Build. IM-21 is manufactured in an FDA-registered facility in the United States.

IM-21 gets its name from 21 active ingredients in the formula. Coincidentally, Mike Tyson was 21 when he unified all three heavyweight titles in 1987.

You can contact IM-21 via the following:

  • Email: support@im-21.com
  • Phone: 866-GET-IM21 (866-438-4621)
  • Mailing Address: 274 W 700 S, Pleasant Grove, UT 84062

IM-21 was founded based on “The Iron Philosophy,” which involves burning away weakness, demanding the best from your body, and building true strength while pushing yourself forward.

Final Word

IM-21 is a nutritional supplement designed to promote anabolism, muscle building, energy, and relaxation. BY taking IM-21 Burn during the morning and IM-21 Build at night, you can target development in two ways, helping you optimize growth.

A lifetime moneyback guarantee backs all IM-21 purchases. If you’re unsatisfied with the supplement for any reason, then you can request a complete refund.

To learn more about IM-21 or buy the supplement online today, visit the official website at IM-21.com.


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