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Best Nootropics (Review) Compare Top Nootropic Supplements

Nootropic supplements are memory and cognition boosters. They are also essential for overall brain health. Students and people in workplaces often use these supplements to boost their memory, enhance their focus, and make them feel more competent.

Some nootropics support blood flow to the brain, while others embrace a blend of herbal extracts, plants, vitamins, and minerals. Whether one is an older adult, a student, or an employee in a competitive environment, nootropic supplements can help one improve their cognitive capabilities and overall brain health.

Entrepreneurs, athletes, and people looking to attain a higher degree of smartness can benefit from nootropic supplements. However, with so many companies and products on the market, it’s often challenging for consumers to pick the right nootropic supplements. This review aims to help consumers overcome this challenge.

Keep reading this guide to discover the best nootropic supplements to consider buying in 2021.

The Best Nootropic Supplements in 2021

Each nootropic supplement promises to increase brain power. While some deliver the promised results, others don’t work. To separate the best from the worst nootropic supplements, our editorial team analyzed several products and companies on the market. We assembled up with the best, science-backed nootropic supplements on the market:

  • SANE Vitaae
  • Mind Lab Pro
  • Nuzena Neuro Focus +
  • NooBru
  • Nootrogen
  • Ageless Brain
  • Onnit Alpha Brain
  • Hunter Focus
  • Qualia Mind
  • Performance Lab Mind
  • Vital Plan Brain Boost
  • NaturalCell NeuroActiv6
  • Synapse XT
  • NooCube
  • Natural Stacks NeuroFuel
  • UpWellness Mind and Mood
  • PureEssence BrainEssence
  • PureHealth Research Ageless Brain
  • Brain C-13
  • Cymbiotika Golden Mind
  • Elm & Rye Nootropics
  • CogniBiotics
  • Amy Myers MD NeuroLive
  • Neuro
  • OptiMind
  • Youthful Brain
  • Oweli Neuro
  • ReMind Solution
  • BrainPill
  • ProMind Complex
  • Memory Hack
  • MemoSurge
  • Memo Defend

To learn more about these nootropic supplements, here’s a rundown of each of them.

SANE Vitaae

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The Vitaae nootropic supplement from SANE Laboratories takes the first slot of the best nootropic formulas in 2021. According to the official website, this leading supplement contains antioxidants such as CoQ10 to target inflammation in the brain. This is contrary to other nootropics that only use herbal extracts, minerals, and vitamins. As stated by SANE Laboratories, Vitaae can help improve brain energy utilization by 13.6% and increase membrane turnover by 26%, among other benefits.

Additionally, SANE Vitaae claims to improve mental clarity and help users enjoy deeper concentration. It also helps them boost their mood and clear brain fog, among others. More importantly, the product is reasonably priced, making it one of the budget-friendly options on this list.

A single supplement serving contains three capsules, including folate, vitamin D, Omega 3 fatty acids, citicoline, Acetyl L-carnitine, and CoQ10. Since Vitaae uses three tablets instead of two per serving, it delivers more ingredients, equating to more noticeable cognitive benefits. SANE Vitaae is currently priced at $47 per package.

Mind Lab Pro

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Mind Lab Pro is one of the nootropic supplements to consider buying in 2021. While it’s more expensive than its competitors, this nootropic supplement works best for those who want to start with nootropic formulas. The manufacturer recommends taking two capsules of Mind Lab Pro per serving, which deliver 11 scientifically verified brain boosters.

Mind Lab Pro uses patented and advanced nutrients such as the popular NutriGenesis vitamins, which maximize bioavailability and absorption. The formula comes with substantial dosages, third-party testing, and clinically verified ingredients, making it one of the best nootropic formulas available online.

Currently priced at $69, Mind Lab Pro is a product of Opti-Nutra, a medically established company that makes health and wellness supplements. Its medical advisory board consists of professionals, including neuroscientists like Dr. Ramon Velazquez, Ph.D. The main ingredients in Mind Lab Pro include Bacopa Monnieri, citicoline, phosphatidylserine, lion’s mane mushroom, and Rhodiola Rosea extract, among others.

Nuzena Neuro Focus +

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The Neuro Focus + from Nuzena is a nootropic supplement designed to support memory recall, cognitive function, and overall mental focus. Made in the United States, this supplement is available to consumers on the official website. The manufacturer recommends buying a minimum of three bottles, making it the only product on this list with that type of offer.

Currently priced at $60 per bottle, Neuro Focus + is one of the best-rated and best-packaged nootropic formulas listed here. Each serving of the supplement delivers considerable doses of several vitamins and minerals. Users can also get up to 692mg of a proprietary blend with glutamic acid, green tea extract, and bilberry fruit extract, among other ingredients.

Most importantly, this supplement comes with one of the best price-to-value ratios on this list. Currently priced at $60, consumers get three bottles of the supplement, which equals 180 capsules. This is enough for three months. Other companies charge the same price for a single bottle.


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This nootropic supplement was launched in 2020, and it has invaded the supplement space for its tasty flavor, thirteen active ingredients, and extensive media attention. NooBru works well across the consumer spectrum serving athletes, students, older adults, and people in competitive workspaces.

Available in powder form, NooBru contains alpha GPC, vitamin B5, L-theanine, choline bitartrate, ashwagandha, and Huperzine, among other proven ingredients. One notable thing about NooBru is its transparency. Unlike other nootropic supplements that hide their active ingredients using proprietary blends, NooBru reveals all its ingredients and dosages upfront.

This allows users to know what they’re getting from each serving of the supplement. Generally, the company uses potent dosages of all its ingredients. Consumers have two options when buying NooBru. The supplement is available in two powders—Shield or Advantage. Importantly, it’s simple to use and requires only water or beverage to mix the powder and drink it daily. Regardless of the version chosen, NooBru delivers an accessible nootropic drink that boosts immunity, energy, cognition, and focus, among other benefits.


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Nootrogen is one of the best nootropic formulas to consider in 2021. The supplement is designed to support energy, cognition, focus, and alleviate stress while improving overall brain health. Like other nootropic supplements on this list, Nootrogen promises the same effects.

However, this formula contains ingredients unavailable from other formulas listed here, such as glutamic acid, L-tyrosine, and DMAE. Each two-capsule serving of the supplement delivers a 642 proprietary blend with herbal extracts, amino acids, and plant extracts that cognition in multiple ways.

One thing to note about Nootrogen is its price. Currently available at $30 per bottle, this formula is more affordable than its competitors on this list. While it offers average dosage, its price-to-value ratio makes it a much more attractive option.

Ageless Brain

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Made by Organixx, Ageless Brain is a dietary supplement currently available at $55 per bottle. The formula contains ingredients similar to other formulas on this list, such as Bacopa Monierri. However, it also uses ingredients unavailable from different formulas on this list, such as cat’s claw, Camu Camu, cacao, guayusa, and cinnamon.

Currently priced at $55, Ageless Brain is ideal for trying something unique, away from the regular nootropic supplements. While more research is still needed to verify the efficacy of its ingredients, this supplement claims to support cognition in several ways using unique active ingredients.

Onnit Alpha Brain

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Onnit Alpha Brain is possible the best-known nootropic supplement currently available online. The supplement is designed to support daily cognition, memory, and focus. Importantly, it enjoys the support of its co-owner Joe Rogan. The Alpha Brain supplement is also one of the few nootropic supplements on this list backed by peer-reviewed research and clinical trials. Unlike other supplement companies that don’t invest in clinical trials, Onnit Alpha Brain delivers a high-quality supplement that gives users an edge over the competition.

So far, the formula boasts more than one million bottles sold, which makes it one of the popular products on this list. Each serving of Alpha Brain delivers a perfect blend of natural ingredients, including Bacopa Monnieri, oat straw, Huperzia Serrata, and cat’s claw, among other proven ingredients that support cognition.

While it uses proprietary formulas, the manufacturers of Alpha Brain reveal individual doses of most ingredients within the proprietary blends. This makes it easy to compare Alpha Brain to other leading nootropic supplements available on the market today. Currently priced at $35 per bottle, Alpha Brain is also an affordable option for anyone looking to optimize cognition.

Hunter Focus

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Made by Roar Ambition, Hunter Focus is a nootropic supplement that claims to give users an edge over the competition. Each serving of the formula improves mental capabilities using all-natural ingredients and a high-quality formula. The main ingredients used in the Hunter Focus supplement include passionflower, Bacopa Monnieri, and phosphatidylserine.

All these ingredients are available in other nootropic supplements on this list. Hunter Focus is considered the intelligent solution to mental fatigue, and the company reveals all dosages upfront. Another essential thing to note about the Hunter Focus supplement is that it uses four capsules per serving, one of the highest dosages on this list. Hunter Focus is currently available at $60 per bottle.

Qualia Mind

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Made by Neurohacker Collective, Qualia Mind is a popular nootropic supplement that delivers powerful benefits. Each supplement bottle comes with 28 brain health ingredients, which work together to support memory, energy, focus, and long-term brain health.

Importantly, Qualia Mid comes with a money-back guarantee. The manufacturer offers a 100-day money-back guarantee on all orders, making it one of the products with the best and most extended guarantees.

Currently priced at $59, Qualia Mind also comes with customized options: The manufacturer offers four nootropic supplements under the Qualia brand, including Qualia Mind, Qualia MiND Essentials, Qualia Mind Caffeine Free, and Qualia Focus. The Qualia Mind brand is currently priced at $59 per bottle.


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This aptly named nootropic supplement is a product of the Performance Lab Company. The effective Mind formula comes in clean packaging. The manufacturer recommends taking the supplement daily to increase brain energy by up to 13.6%. It also supports memory and focus, boosts motivation, and improves recovery from intense cognitive exertion.

According to the manufacturers, the formula uses citicoline, phosphatidylserine, L-tyrosine, and maritime pine bark extract to deliver its benefits. These ingredients work together to supply the body with antioxidants, minerals, vitamins, and other nutrients it needs to support cognition in multiple ways. A bottle of the Mind supplement currently costs $69.

Brain Boost

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This nootropic supplement from Vital Plan is another top-rated brain booster to consider in 2021. Developed by Dr. Bill Rawls, MD, Brain Boost claims to support cognitive function and boost mental clarity. It also enhances focus, immunity, natural energy, and natural energy while alleviating stress and improving the gut microbiome.

Brain Boost embraces natural ingredients such as Bacopa Monnieri, Ashwagandha, Ginkgo Biloba, cat’s claw extract, and lion’s mane mushroom, among others, to achieve its benefits. Notably, the formula comes with transparent labeling and effective dosages. It contains no proprietary formulas, making it one of the best brain-boosting options to consider in 2021.

Additionally, Brain Boost is among the few nootropics on this list that offer four capsules per serving. At $48 per bottle, it provides value for money and is one of the most potent nootropics on this list.


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This powdered nootropic formula is a product of NaturalCell. NeuroActiv6 is available in the form of a high-powered powder that works to boost brain health, improve focus, and enhance clarity, among other benefits. According to the manufacturer, users should add one scoop of the formula to their beverage of choice.

It restores brain energy, boosts BDNF levels, and prevents oxidative stress. Additionally, NeuroActiv6 supports healthy cortisol levels and promotes neural communications alongside other benefits. The supplement contains a wide range of superfoods such as grape seed extract, ashwagandha, turmeric, citicoline, B vitamins, and coffee fruit extract.

This nootropic supplement is ideal for those looking to quickly boost their brainpower by including active ingredients in their daily smoothies. Currently available for only $46 per jar, NeuroActiv6 is among the most affordable options on this list. Besides, it comes with a 60-day money-back guarantee. The company advocates for maximum transparency by revealing most of its dosages upfront.

Synapse XT

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This nootropic formula is a blend of herbs, vitamins, minerals, and plant-based components that work together to support brain health and hearing health. Older adults with hearing and cognitive problems can benefit from the Synapse XT formula. The manufacturer recommends taking two formula capsules daily to help users with memory, hearing, and focus.

Synapse XT achieves its benefits by improving the communication between the cells and reducing the signs of brain fatigue. According to the manufacturer, the formula also supports the perception of senses and sounds, leading to clear thinking and hearing.

Synapse XT currently costs $69 per bottle, making it one of the more expensive formulas on this list despite its average list of ingredients. Even so, it could be the best choice for those looking to support brain and hearing health.

NooCube Brain Productivity

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Developed by top neuroscientists, NooCube Brain Productivity is a nootropic supplement with no caffeine. Unlike other brain supplements, this formula uses unique ingredients, including plant extracts, herbal extracts, alongside other active ingredients that support cognition in multiple ways.

NooCube Brain Productivity embraces natural ingredients, including Alpha GPC, Bacopa Monnieri, cat’s claw extract, and Huperzine A. Importantly, the formula comes with a 60-day money-back guarantee is a testimony for the manufacturer’s confidence in the product. Priced at about $60 per bottle, NooCube Brain productivity delivers good value without compromising quality, dosages, or ingredients.


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This nootropic supplement is a product of Natural Stacks. It targets brain fog, memory, cognition, and many more. While it’s similar to other nootropics on this list, NeuroFuel offers a unique advantage over its competitors. It uses blockchain technology to track all ingredients and sources. This makes it the only “open-source” nootropic on this list.

Apart from the blockchain, NeuroFuel contains active ingredients such as artichoke extract (900mg), acetyl L-carnitine (750mg), forskolin, and vitamin B6 to enhance cognition in multiple ways. The formula delivers substantial doses of fewer ingredients instead of small quantities of many elements. Currently priced at $30, NeuroFuel is among the more affordable and effective formulas on this list.

Mind & Mood

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This brain health supplement is a product of UpWellness. While other nootropic formulas support cognition, memory, and focus, the Mind & Mood brain health formula targets anxiety, stress, and emotions. The manufacturer recommends taking the supplement daily to enjoy a calmer and more relaxed nervous system.

Mind & Mood promotes emotional health and stress management with adaptogenic ingredients such as 5-HTP, Rhodiola Rosea, GABA, saffron, and L-theanine, alongside other components. Developed by Dr. Joshua and Dr. Amanda Levitt, this nootropic supplement is also among the few formulas on this list formulated by real doctors. A bottle of Mind & Mood currently costs $57.


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Made by PureEssence, BrainEssence is a nootropic supplement designed to support memory, energy, mood, mental clarity, and overall brain health. BrainEssence is available in tablet form and not a capsule. Users should take two tablets of the formula daily to boost their cognition in multiple ways.

To confirm its transparency, PureEssence reveals all ingredients and dosages upfront. This allows consumers to view what they put into their bodies with each serving of the formula. BrainEssence delivers significant doses of acetyl L-carnitine (500mg), ashwagandha (200mg), and Bacopa Monnieri extract (300mg).

It also delivers smaller quantities of Rhodiola Rosea, Chinese club moss extract with Huperzine, and alpha-lipoic acid (ALA). BrainEssence is also more expensive than its competing options, available at $30 for 15 servings.

PureHealth Research Ageless Brain

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This list contains two “Ageless Brain” supplements. Unlike the previously mentioned supplement from Organixx, this formula is from PureHealth Research. With a 365-day money-back guarantee, this formula is also among the formulas developed by a real doctor—Dr. Holly Lucille.

The Ageless Brain supplement from PureHealth Research embraces natural ingredients including GABA, B vitamins, caffeine, and Huperzine A, alongside other elements that supercharge cognition in several ways. According to the manufacturer, users should take one capsule of the Ageless Brain supplement daily to decrease anxiety and clear brain fog.

Besides, it improves memory and focus while boosting memory and cognitive wellness, among other benefits. The main disadvantage of the formula is that it uses a proprietary formula. While it’s known that the formula contains 600mg of active ingredients in its proprietary blend, but no one knows the actual breakdown of each component used in the formula. However, for those who don’t mind dosage transparency, Ageless Brain could be a suitable option. The product is currently priced at $44.

Brain C-13

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Brain C-13 is a product of Zenith Labs. This nootropic supplement contains vitamins, minerals, and herbal extracts similar to other products on this list. Key ingredients in this formula include Rhodiola root extract, DMAE, turmeric, rosemary leaf, ginkgo leaf, phosphatidylserine, and Huperzine A, among other elements.

Zenith Labs is known for its transparency. It reveals all its dosages and ingredients upfront, which makes it easy for consumers to compare the supplement with other top-rated formulas on this list. Besides, it embraces three capsules per serving, putting it among the supplements with more substantial dosages than others with one or two capsules per serving.

Currently priced at $49, Brain C-13 is also among the supplements on this list formulated by doctors. It also enjoys the support of a medical advisory board.

Cymbiotika Golden Mind

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Formulated by Cymbiotika, Golden Mind is one of the best nootropic supplements to consider buying in 2021. It’s the only supplement in this list available in a tincture form instead of capsule or powder. Each serving of the Golden Mind supplement delivers natural ingredients like lion’s mane powder extract, organic phosphatidylserine, Rhodiola Rosea, and L-theanine, alongside other components.

At $50 per bottle, Golden Mind also comes with other ingredients unavailable from other nootropics such as Gotu kola extract, buckthorn oil, and a blend of 82 ocean minerals, among other unique elements. According to the manufacturer, users should take Golden Mind daily to help protect the brain, nurture brain cell growth, and reduce brain fog, among other benefits.

Elm & Rye Nootropics

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Elm & Rye Company sells a nootropic formula called Nootropics. At $85 per bottle, this supplement is the highest-priced option on this list. The manufacturer uses natural ingredients to enhance memory and focus while improving attention and improving productivity and stamina.

Each serving of the Nootropics formula delivers potent ingredients such as Bacopa Monnieri, GABA, L-theanine, phosphatidylserine extract, L-tyrosine, and B vitamins alongside other components. Besides, each formula serving comes with a strong dose of caffeine (268mg), similar to drinking two or three cups of coffee at once. This nootropic supplement is ideal for those looking to get an instant jolt combined with other proven nootropic supplements.


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This nootropic blend claims to enhance brain health, learning, mental clarity, memory, and focus. Unlike other nootropic supplements on this list, CogniBiotics optimizes digestion—not by explicitly targeting the brain. Bad gut health can easily cause impaired digestion. The gut bacteria play an essential role in brain performance. At $62 per bottle, it’s among the more expensive options on this list.

CogniBiotics has up to 17 nootropic and adaptogenic components that support cognitive function, mood, and stress by keeping the gut flora at optimal levels. It also delivers ten probiotic bacteria strains that support bacteria levels in the gut. This nootropic supplement is ideal for improving brain health uniquely compared to other nootropic formulas on this list.

Amy Myers MD NeuroLive

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NeuroLive is a product of Amy Myers, MD. It’s a doctor-formulated and recommended nootropic supplement, which works as a premium cognitive booster. It comes with seven high-profile brain-boosting micronutrients putting it among the best nootropic supplements to consider using in 2021.

Key ingredients in this formula include vitamin B6 and a proprietary blend of Bacopa Monnieri whole plant extract. It also contains Ginkgo Biloba leaf extract, Mucuna Pruriens seed extract, Acetyl L-tyrosine, and L-theanine, among other powerful ingredients that support cognition and overall brain health in several different ways.

The ingredients in this formula work in synergy to combat free radicals and help win the fight against oxidative damage. Notably, the formula uses a patented brain cell support ingredient—the Sharp PS GREEN phosphatidylserine ingredient. With a unique combination of active ingredients, the formula supports energy production in the brain and several health benefits.

Currently priced at $49.97, NeuroLive also comes with a 90-day money-back guarantee. The product also undergoes third-party lab testing to verify its efficacy in improving cognitive function and overall brain health.


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This product is the only nootropic supplement on this list available in the form of gums and mints. By taking Neuro gums or mints daily, users can receive a wave of energy, calmness, and mental focus. According to the manufacturer, Neuro offers three lineups of gums and mints: Energy & Focus, Calm & Clarity, and Ideal State. A pack of Neuro currently costs at least $21.

These supplements work to help users energize in the morning, optimize their mood and clarity during mid-day, and enjoy a sense of wellbeing throughout the day. Some users prefer taking a mint or chewing a piece of gum instead of swallowing a pill. With active ingredients such as peppermint and cinnamon flavors, Neuro provides a suitable choice for those looking to boost their cognitive function through mint and gum options.


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OptiMind is one of the best-rated nootropics to consider using in 2021. The formula works to promote mental energy, focus, and cognition. Priced at $39 for 16 servings (32 capsules), this formula improves energy, focus, understanding, and mental clarity, among other benefits.

The chief active ingredient in this formula is Bacopa Monnieri, with 55% bacosides. Bacosides are the active chemicals in the Bacopa Monnieri plant that deliver beneficial properties. The OptiMind supplement contains these chemicals that help users enjoy powerful cognitive support alongside other benefits.

Youthful Brain

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This nootropic supplement is a product of Vitality Now. Currently, at $65 per package, this formula supports cognition, mental energy, and overall brain health by using several active ingredients.

Youthful Brain’s key ingredients include vitamin B12, Bacopa Monnieri, and Huperzine A, alongside other components. Overall, the formula contains similar ingredients to other nootropics on this list. One thing that separates it from the competing options is its higher price tag, which puts it among the more expensive options listed here. It also has lower dosages.

Oweli Neuro

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Simply known as Neuro, the Oweli Neuro Brain & Focus Formula is a unique nootropic supplement that supports Zen-like focus. According to the manufacturer, users should take two capsules of Neuro supplement daily to help improve their memory and learning while supporting neuroplasticity. It also helps fight age-related cognitive decline alongside other benefits.

Each serving of Neuro consists of two capsules, which contain ingredients that boost concentration, memory, mood, stress, and productivity. The main ingredients in this formula include Bacopa Monnieri, Huperzine A, inositol, DMAE, phosphatidylserine, and B vitamins, similar to other nootropics on this list. At $30 per bottle, Neuro is among the options with the best value on this list.

ReMind Solution

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Simply referred to as ReMind, this nootropic supplement uses clinically certified supplements to combat anxiety, stress, cognitive issues, and focus problems, among others. A bottle of ReMind costs $69 for a 30-day supply, putting it among the highest-priced options on this list.

The main downside of the ReMind formula is its price-to-value ratio. While its price is higher, the formula offers fewer advantages than other options in the same range.

However, the formula is backed by a two-month money-back guarantee, which makes it easy for consumers to ask for a refund if they are unsatisfied with its effects. Additionally, the manufacturer offers further discounts on multiple orders starting from three bottles and more.


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This formula is advertised as an “unfair advantage over the competition.” It claims to combat mental fatigue while eliminating brain fog. It also protects and boosts memory, ignites rapid recall, sustains cognitive energy, and improves learning abilities, among others.

Each serving of the supplement contains 13 nootropics to deliver an all-day focus without the crash. BrainPill is also among the few nootropic supplements on this list recommended by a medical doctor (Dr. Dave David). The formula claims to enhance cognition without creating any adverse side effects. Besides, unlike other formulas listed here, BrainPill contains no caffeine.

The supplement stimulates brainpower by delivering active ingredients such as tyrosine, L-theanine, citicoline, and vitamin B12, and more. While the manufacturer says all the right things about the product, the price is higher. At $69 per bottle, it’s one of the expensive options on this list, even with lower dosages.

Additionally, the manufacturer is not transparent with all the dosages of many ingredients within the formula. The company only claims to use “hefty” or “proper” doses of active ingredients without revealing the actual components upfront. This lack of clarity pushes it further down the spectrum regarding the best nootropics to consider using this year.

ProMind Complex

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Developed by Carl Henderson, the ProMind Complex claims to boost cognition using specific natural ingredients. The developer claims to have used decades of experience to create the perfect nootropic supplement. While Carl and his team are correct about the formula, the formulation falls short, considering its active ingredients and dosages.

The main ingredients used in ProMind Complex are L-glutamine, Bacopa Monnieri extract, vinpocetine, Huperzine A, and phosphatidylserine, all of which are popular for their nootropic properties. However, the formula offers surprisingly low dosages considering its steep price.

Overall, ProMind Complex is the smallest nootropic on our list, with just 30 capsules per bottle, equating to 30 servings. However, it could be the right choice for those who are looking for a unique formula.

Memory Hack

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Made by Nutrition Hacks and priced at $69 per bottle, Memory Hack is one of the higher-priced options on this list. However, it falls short on the ingredients and dosages to support its high price tag. Additionally, the biggest issue with this formula is its advertised benefits.

According to the manufacturer, the Memory Hack supplement can help people with memory problems experienced “total restoration of memory in six months.” But they have no proof to justify the claim. This looks like an exaggerated statement meant to give people with memory disorders unrealistic expectations.

All the same, the formula comes with a 60-day money-back guarantee with all orders accompanied by a bonus guide. This somehow makes it easy for consumers to maximize the value of their purchase.


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This dietary supplement claims to accomplish its benefits in a three-step process. To begin with, it fires up neurotransmitters in the brain. Secondly, it repairs damaged brain cells while eradicating brain shrinkage. Finally, MemoSurge helps users get rid of anxiety and insomnia and boosts their energy levels.

The supplement also promises to optimize overall health and wellbeing alongside other benefits. Currently priced at $69 per bottle, MemoSurge is among the more expensive nootropic supplements on this list. However, it provides little details about the ingredients, dosages, and concentrations within the formula, making it difficult to compare with other competing options.

Memo Defend

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Created by researcher Thomas Taylor, this nootropic supplement claims to use natural ingredients to boost cognition in multiple ways. Like other nootropics with limited information on this list, Memo Defend reveals little information about its dosages, components, or lab testing.

Its core consists of a 620mg proprietary blend with olive leaf, garlic bulb, and Hawthorn leaf. However, none of these ingredients are linked to notable cognitive improvement in any scientific or research studies. The most significant element in Memo Defend is vitamin B12, a component of nearly every supplement sold online. Memo Defend is priced at $69.

How We Rated the Best Nootropic Supplements

All nootropic supplements promise the same benefits—to help users improve their cognition with natural ingredients. However, only the best nootropics can fulfill that promise. After analyzing lab reports, engaging manufacturers, and doing other due diligence, our editorial team used the following metrics to rank the best nootropic supplements listed here.

Scientifically verified ingredients

Some ingredients are science-backed by multiple studies to support cognition. After several years of research, it’s evident that plant extracts, vitamins, minerals, and herbal extracts can enhance brainpower in most individuals when taken in recommended dosages. This list preferred nootropics that use scientifically verified ingredients and dosages, putting them at the top of the list.

Effective dosages

Several nootropic supplements use the right ingredients but miss the dosages. For instance, a supplement could have a dozen active ingredients with small dosages to effectively impact the human body.

Transparent Advertised Benefits

Some nootropic manufacturers exaggerate the benefits of their products. For example, some companies claim their products can make the brain several years younger while supercharging memory and cognition. The best nootropic manufacturers maintain honesty and transparency in their advertised benefits.

Proprietary blends

Several supplements embrace proprietary blends. For the nootropics, unfortunately, many manufacturers use proprietary blends to hide weak dosages. Some companies also use proprietary blends to conceal stimulants like caffeine. This makes some formulas go off-track regarding their targeted benefits.

For instance, while users may think they’re improving their mental energy by a nootropic supplement, they could be getting a higher dose of caffeine hidden in the proprietary blend.

Doctor formulated

Some of the best nootropic formulas are products of real medical doctors or naturopaths (NDs). Others enjoy the approval of an in-house medical advisory board. This list considered nootropic supplements with multiple professional certifications to rank higher.

Manufacturer reputation and lab testing

Some companies collaborate with third-party labs to test their supplements. Others have many years of experience developing effective supplement formulas. While this list preferred manufacturers with a proven reputation for producing effective formulas, it’s not biased towards older companies.

Customer reviews and subjective experiences

Individual results can vary while using nootropic supplements. This list compared customer reviews and personal experiences to help with ratings.

Price and value

Some consumers can spend upwards of $200 monthly on nootropic supplements. Others can only afford $20 per month. This list preferred nootropic formulas that offer the best value at any price. The list contains a range of nootropics at different prices without comprising a good deal.

Clinical trials and peer-reviewed research

Most nootropic supplement manufacturers don’t invest in clinical trials, claiming that they are expensive and time-consuming. However, nootropics are becoming more popular, and many companies now invest in clinical trials or published research in peer-reviewed journals. This gives such manufacturers an additional layer of legitimacy over their competitors.

Money-back guarantee

Top-rated nootropic supplement manufacturers support their products with a money-back guarantee. This list preferred manufacturers that provided consumers with a money-back guarantee or similar assurances to win their confidence in the product.

Nootropic Supplement Benefits: What Does Science Say?

All nootropic companies make strong claims about their effects and benefits. However, do these brain-boosters work? How do nootropics work? What is the scientific perspective? Do clinical trials and peer-reviewed research support nootropics?

While it was a little-known field of research a few years ago, nootropics have ballooned into popularity in recent years. Today, many peer-reviewed research studies support specific nootropic formulas. For instance, some of the best nootropic supplements use science-backed ingredients.

Bacopa Monnieri is one of the most widely used chief ingredients in nootropic formulas. This herbal extract has been used in Chinese traditional medicine for hundreds of years. In one clinical trial, the ingredient was found to “improve higher order cognitive processes.”

In the same trial, Bacopa Monnieri was found to be particularly effective in enhancing learning and memory. Many other scientific studies have linked it to improved memory, reduced reaction times, and enhanced information processing.

Another widely used ingredient in nootropic supplements is Ginkgo Biloba. Like Bacopa Monnieri, this plant extract has been used in traditional Chinese medicine for centuries. Modern scientific research equally links it to cognitive improvement. In one study, researchers found Ginkgo Biloba and vinpocetine, another nootropic ingredient, to improve memory and faster response times.

Similarly, ashwagandha is a popular adaptogen found in top-rated nootropic formulas. This plant has been used in traditional Indian medicine for ages to support relaxation, cardiovascular health, sleep, stress management, and more. In a 2016 study, researchers discovered this plant also had “nootropic potential.” According to the study, ashwagandha displayed mind-protecting effects by targeting neurotoxins in the brain that would typically impede memory and cognition.

Similarly, Huperzine A is one of the widely used nootropic ingredients that has been on the researchers’ radar for a long time. In a 1999 study, Chinese researchers found it could help with cognition and memory while alleviating the symptoms of Alzheimer’s disease. This makes it one of the most promising clinically verified nootropic ingredients.

Other ingredients used in the formulation of nootropic ingredients, including L-theanine, Korean Ginseng, and caffeine, are science-backed to help with cognition and memory, among other health benefits.

Overall, top-rated nootropic supplements available on the market today utilize science-backed ingredients to promote cognition, mood, memory, and focus, among other benefits. Users should be on the lookout for scientifically proven ingredients and dosages to ensure they maximize the benefits of their nootropic formulas.

Nootropic Dosages

Nootropic formulas contain a combination of different ingredients. Consumers should follow the recommended dosage instructions on a particular nootropic product. For most encapsulated nootropic supplements, users should take one or two capsules once or twice daily to help with cognition issues.

Other nootropic products are available as a powder. For such products, users should add one scoop of the formula to water, beverage, or a shake and drink daily to boost their brainpower. Notably, users should check the nootropic label for any proprietary blend to confirm the dosages.

Top-rated nootropic products disclose their dosages and ingredient sources. However, some manufacturers also use proprietary labels. Such products may not be ideal for caffeine-sensitive users, as they hide actual ingredients and dosages.

Nootropic Supplements Side Effects

So far, nootropic supplements bear no significant side effects when used in the proper dosages by healthy adults. However, individual results may vary, and some people might experience mild digestive discomfort, nausea, headaches, and other mild symptoms while consuming nootropics.

Users that follow the recommended dosage instructions on their nootropic formulas and have no underlying health conditions are unlikely to experience notable side effects from a nootropic supplement. Many nootropic supplements also contain plant-based ingredients and herbal extracts, mushroom extracts, and other ingredients.

While it’s rare, some people might be allergic to these ingredients. Other nootropic products also contain caffeine and other stimulants, which could cause jitters, nausea, chest tightness, anxiety, and other side effects when used in high dosages. Users should stop using a nootropic product if they experience significant side effects.

Importantly, they should consult their medical providers before using a nootropic formula. This is necessary for those already taking medication or who have an underlying medical condition.

Best Nootropic Supplements Final Word

Nootropic supplements are getting more popular every day. Currently, users can buy nootropic supplements online or in third-party offline stores to boost their brainpower. The best nootropic supplements help users optimize memory, cognition, focus, and learning capabilities, among others.

Nootropic products are beneficial to nearly everyone, including older adults, athletes, workers in competitive environments, and students looking for an edge. Before getting started with any nootropic supplement, users should research by reading reviews like this one. It’s equally important to buy a nootropic supplement from the official website or authorized sellers.

RELATED: Mind Lab Pro Review: No Negative Complaints or Side Effects?

Affiliate Disclosure:

The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team and please know we only recommend high quality products.


Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.

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